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(34) Given the increased risk of sarcopenia, osteoporosis, and frailty in older adults, future research should explore the long-term effects of GLP-1 receptor agonists on musculoskeletal health in this population, alongside their established systemic benefits

As we have mentioned above that endogenous GLP-1 has a very short half-life (around 2 min) due to the existence of the degradation enzyme DPP-4

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Gastrointestinal side effects like nausea and bloating typically appear during the initial doses and peak within the first 48 weeks as the dose is gradually increased